线粒体激活剂BGP-15保护精子质量免受氧化损伤,并改善胚胎发育能力
Macarena B Gonzalez1, Nicole O McPherson2, Haley S Connaughton1
1School of Biomedicine, Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
F&S science
|December 15, 2024
概括
线粒体激活剂BGP-15通过减少细胞损伤和氧化应激来保持精子质量. 这种化合物显示出在辅助生殖技术 (ART) 程序中改善结果的潜力.
科学领域:
- 生殖生物学和医学生殖生物学和医学
- 线粒体功能和细胞保护
背景情况:
- 精子质量对于男性生育能力和成功的辅助生殖技术 (ART) 结果至关重要.
- 细胞损伤,包括氧化应激,对精子参数产生负面影响,如运动性和DNA完整性.
- 线粒体功能障碍是导致精子损伤的关键因素.
研究的目的:
- 评估线粒体激活剂BGP-15在保持精子质量的有效性.
- 评估BGP-15对精子细胞损伤和氧化应激的保护作用.
- 确定BGP-15提高ART成功率的潜力.
主要方法:
- 用BGP-15.5进行小鼠和人类精子体外治疗.
- 对精子质量标志物的评估:运动性,线粒体膜潜力,DNA碎片化和DNA氧化.
- 用经过处理的精子进行体外受精后对植入前胚胎发育和后代结果的评估.
- 研究包括老年小鼠和受催氧化应激的人类精子,以及接受ART的患者.
主要成果:
- 在老年小鼠中,BGP-15显著改善了精子运动性和线粒体膜潜力.
- 在氧化应激下的人类精子中,BGP-15增加了45%的运动性,并分别减少了45%和60%的DNA碎片化和氧化.
- 接受ART治疗的男性的精子在接受BGP-15治疗后,其运动率增加了12%,DNA损伤减少了20%以上.
结论:
- BGP-15有效地保护精子免受细胞损伤和氧化应激.
- 该化合物显示出提高精子质量的潜力,以改善ART结果.
- BGP-15代表了男性不孕症和生育治疗的有前途的治疗剂.
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