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在怀孕早期暴露于多环芳化合物对儿童神经发育的影响

Zhi Li¹, Yu Han¹, Xinyu Li¹

¹Department of Maternal, Child and Adolescent Health, School of Public Health, Tianjin Medical University, No. 22 Qixiangtai Road, Tianjin, 300070, China.

Environmental pollution (Barking, Essex : 1987)

|December 15, 2024

概括

怀孕期间接触多环芳 (PAH) 会对儿童的神经发育产生负面影响,特别是社会和语言技能. 这项研究强调了早期发育中PAH混合物和单个代谢物的风险.

科学领域:

环境健康环境健康
神经科学是一个神经科学.
毒理学毒理学毒理学

背景情况:

关于怀孕期间和儿童神经发育期间暴露于多环芳 (PAHs) 的非确的流行病学证据存在.
多氧化是一种环境污染物,可能对发育中的大脑产生不利影响.

研究的目的:

评估妊娠早期暴露于PAH代谢物和婴儿神经发育结果之间的关联.
研究单个PAH代谢物及其混合物对儿童发育的影响.

主要方法:

在中国天津,对172对母子对进行前性队列研究.
通过气体染色学和双重质谱法 (GC-MS/MS) 在母亲尿液中定量十种PAH代谢物.
评估儿童神经发育使用格里菲斯发育尺度-中文 (GDS-C) 在6-12个月的年龄.
使用多变量线性回归,加权量子总和 (WQS) 回归和贝叶斯内核机器回归 (BKMR) 的统计分析.

主要成果:

六种PAH代谢物与个人社会评分有负面关联,三种与语言评分有关.
WQS和BKMR模型表明,PAH混合物与个人社会和语言分数的降低有关.
鉴定出1-氨,3-氨和3+9-氨是对神经发育不良结果的关键贡献者.

结论:

在怀孕早期暴露于PAHs,单独或作为混合物,与儿童神经发育有负面关联.
这些发现强调了在怀孕期间减少PAH暴露的重要性,以保护儿童的神经发育结果.

关键词:

贝叶斯核心机器回归 (BKMR)儿童的神经发育儿童的神经发育多环芳香碳化合物多环芳香碳化合物产前暴露在产前暴露.权重定量总和 (WQS) 回归方法

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