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Updated: Jun 5, 2025

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases
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Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases

Published on: August 27, 2021

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重定向E3无素连接酶用于具有异质识别域的向蛋白质降解

Huan Yang1, Ge Zheng1, Grace Y Li2

  • 1Department of Pediatrics, Dana Farber/Boston Children's Hospital Cancer and Blood Disorder Center, Boston, Massachusetts, USA; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

The Journal of biological chemistry
|December 15, 2024
PubMed
概括

研究人员探索了TRIM10和TRIM58 E3连接酶对BCL11A的向蛋白质降解. 这一策略使红色素细胞的选择性蛋白质耗尽成为可能,为血红蛋白病变提供了新的治疗途径.

关键词:
在 BCL11A 中.E3 无处不在酸接酶这就是 PROTACs.在 TRIM10 中,在TRIM58中,我们使用了TRIM58.有针对性的蛋白质降解降解.

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