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SARS-CoV-2主要蛋白酶的zymogene形式:药物发现的离散目标

Pavel Novotný1, Jana Humpolíčková2, Veronika Nováková3

  • 1Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Science, Department of Physical and Macromolecular Chemistry, Charles University in Prague, Prague, Czech Republic.

The Journal of biological chemistry
|December 15, 2024
PubMed
概括

研究人员开发了研究SARS-CoV-2主要蛋白酶 (Mpro) 处理的工具. 他们找到了分离前体Mpro的方法,并确定了针对成熟和前体形式的抑制剂,有助于理解病毒生命周期.

关键词:
佛斯特共振能量转移 (FRET) 是一个在SARS-CoV-2中,主要的蛋白酶是SARS-CoV-2.激活方式 激活方式自动处理自动处理.基于细胞的测定.光交叉关联光谱学 (FCCS) 是一种光终身成像 光终身成像抑制剂抑制剂的使用成熟 成熟 成熟 成熟.在NSP5中,nsp5是什么?一个前体的前体.蛋白质酶蛋白质酶是一种蛋白质.病毒 病毒 病毒 病毒

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