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科迪塞通过促进通过自性途径促进STING降解来改善自身免疫力

Daidi Yang¹, Niannian Peng², Hongqian Zhang³

¹Department of Ophthalmology, The First People's Hospital of Wuhu, Wuhu, China.

British journal of pharmacology

|December 15, 2024

概括

作为一种天然化合物,Cordicepin抑制了STING激活,并减少了I型干扰素的产生,通过促进STING降解,为狼等自身免疫性疾病提供了潜在的治疗方法.

科学领域:

免疫学免疫学免疫学
分子生物学分子生物学
药理学药理学是指药理学的学科.

背景情况:

干扰素反应刺激器cGAMP交互器1 (STING) 是cGAS-STING通路的核心,调节I型干扰素 (IFN).
过度活跃的STING信号与自身免疫性疾病如系统性红斑狼 (SLE) 有关.
用免疫调节剂向STING可能会抑制自身免疫力.

研究的目的:

为了研究cordycepin对STING介导的I型IFN产生的影响.
评估cordycepin作为治疗自身免疫和自身炎症疾病的治疗剂的潜力.

主要方法:

实验室模型:来自SLE患者的PBMCs,Hela细胞,L929细胞和小鼠BMDMs.
在体内模型:Trex1 KO小鼠.
测试方法:西式涂抹,PCR,双露西法酶,ELISA,H&E染色,RNA-seq以评估I型IFN的产生和治疗后的反应.

主要成果:

科迪塞宾抑制了通过cGAS-STING激活的人类和小鼠系统的I型IFN产生和反应.
在Trex1 KO小鼠和BMDM中,康迪塞平减弱了自身炎症和自身免疫反应.
科尔迪塞宾减少了SLE患者PBMC的I型IFN和干扰素刺激基因.
机制:Cordicepin在DNA刺激时通过自促进了STING降解.

结论:

科迪塞宾促进了STING自降解,缓解了由DNA触发的自身免疫反应.
科迪塞宾显示作为治疗候选人管理异常类型I IFN活动在自身免疫性疾病的承诺.

关键词:

刺痛是一种刺痛.自身免疫性疾病是一种自身免疫性疾病.自自是自的过程.科尔迪斯皮恩是什么意思具有天生的免疫力.

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