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胆囊切除术后肠道微生物组的变化和临床影响:用叙述合成进行系统审查
Tiing Leong Ang1,2,3,4, Seok Hwee Koo5, Daphne Ang1,2,3
1Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.
Journal of gastroenterology and hepatology
|December 15, 2024
概括
胆囊切除术 (CCE) 显著改变了肠道微生物群,导致了肠道功能失调. 需要进一步的研究才能充分理解这些变化及其临床影响.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 外科手术的结果
背景情况:
- 胆囊切除术 (CCE) 影响胆酸循环和肠道微生物组成.
- 了解这些后CCE肠道微生物组的变化对于临床管理至关重要.
研究的目的:
- 系统地审查CCE对肠道微生物组组成的影响.
- 为了澄清CCE诱导的肠道失调症的临床影响.
主要方法:
- 在PubMed,科学网络和Scopus上进行系统的文献搜索.
- 包括的研究分析了胆囊切除术后肠道微生物组的变化.
- 使用纽卡斯尔-太华尺度评估研究质量.
主要成果:
- 14项研究显示,在CCE后,肠道微生物组发生了显著但不一致的变化.
- 观察到的微生物多样性 (alpha和beta) 和属/属丰度的变化.
- 在诸如胆囊切除术后腹和综合征等疾病中观察到的特定变化.
结论:
- 接受CCE的患者表现出显著的肠道失调.
- 在CCE后的细节性结构和功能性肠道微生物变化仍然不清楚.
- 需要进一步的研究来阐明CCE对肠道微生物群的确切影响.
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