化疗与胃癌患者的免疫治疗相结合:系统性审查的协议
Yihui Han1,2, Wenming Yang3, Yang Meng4
1Department of General Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
BMJ open
|December 15, 2024
概括
本系统性审查审查了结合化疗和免疫疗法治疗胃癌的方法. 它评估了免疫检查点抑制剂 (ICI) 在术后和全身治疗中的好处和缺点,以指导未来的研究.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胃肠道瘤学 胃肠道瘤学
背景情况:
- 胃癌治疗的进展整合了化疗和免疫疗法,建立了新的护理标准.
- 现有的系统性审查对免疫检查点抑制剂 (ICI),抗体类型和治疗方式的范围有限.
- 需要对组合治疗的好处和缺点进行全面评估,以指导未来的研究和患者护理.
研究的目的:
- 进行对最近关于胃癌联合治疗的临床研究的系统审查.
- 综合评估免疫疗法联合治疗与单独化疗的好处和缺点.
- 为胃癌患者提供基于证据的支持,并指导未来的研究.
主要方法:
- 遵守系统审查和元分析的首选报告项目 - 协议 (PRISMA-P) 准则.
- 系统地搜索MEDLINE,Embase和CENTRAL数据库中的随机临床试验.
- 包括比较免疫疗法联合治疗与单独化疗在胃癌外科和一线全身治疗中的试验.
主要成果:
- 主要结局包括无进展生存 (PFS) 和整体生存 (OS).
- 二次结果包括客观反应率 (ORR),无事件生存率 (EFS),无疾病生存率 (DFS),病理完整反应 (pCR),主要病理反应 (MPR) 和R0切除率.
- 调查异质性和出版偏见,并进行潜在的元分析和子组分析.
结论:
- 这一系统性审查将全面评估结合化疗和免疫治疗在胃癌中的疗效和安全性.
- 结果将为临床决策和未来研究方向提供基于证据的指导.
- 这项研究旨在加强治疗策略,改善胃癌患者的治疗结果.
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