结肠镜检查不同肠道制剂的比较疗效:一个网络的元分析
概括
结肠镜检查的最佳肠道制剂是2升PEG含有西米西康或乳糖,1升PEG含有酸盐,具有很高的清洁成功率. 只有2L的PEG与西美西康也改善了腺瘤检测率.
科学领域:
- 胃肠病学 胃肠病学
- 内镜检查是指内镜检查.
- 药理学 药理学是指药理学的学科.
背景情况:
- 结肠镜检查的质量取决于有效的肠道清洁.
- 不同的肠道制备溶液的比较有效性是不确定的.
研究的目的:
- 通过系统性审查和网络元分析,比较不同肠道准备器的结肠镜检查的性能.
主要方法:
- 在MEDLINE,Embase,Scopus和Cochrane图书馆对RCT进行系统搜索.
- 主要结果:清洁成功 (CS). 二次结果:腺瘤检测率 (ADR).
主要成果:
- 2 L PEG + 赛美西康,2 L PEG + 乳糖,1 L PEG + 亚斯酸盐与2 L PEG + 亚斯酸盐相比显示出更优异的CS.
- 2 L PEG + 乳糖 (SUCRA 0.94) 和 2 L PEG + 赛美西康 (SUCRA 0.93) 是对CS最有效的.
- 只有2L的PEG+西梅西康显著改善了ADR (RR=1.60).
结论:
- 对于高CS,推使用2L PEG + simethicone,2L PEG + 乳糖和1L PEG + 酸盐.
- 2 L PEG + simethicone 是首选的,因为它显著改善了ADR.
- 需要进一步的研究来比较这些制剂的ADR.
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