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使用PASTE对哺乳动物细胞进行精确的千基基量基因组插入.

Christopher W Fell1,2,3,4, Cian Schmitt-Ulms1,2,3,4,5, Dario V Tagliaferri1,2,3,4

  • 1Harvard Medical School, Harvard University, Boston, MA, USA.

Nature protocols
|December 15, 2024
PubMed
概括

通过特定地点向元件 (PASTE) 进行可编程添加,可以在哺乳动物基因组中进行精确,高效和大规模的DNA插入. 这项技术为基因整合应用提供了改进的编辑,纯度和可编程性.

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