老龄化与种族多样性的代谢异质性:更接近健康老龄化的一步
Dakshat Trivedi1,2, Katherine A Hollywood3, Yun Xu1
1Centre for Metabolomics Research (CMR), Department of Biochemistry, Cell, and Systems Biology, Institute of Systems Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Metabolomics : Official journal of the Metabolomic Society
|December 15, 2024
概括
血清代谢显示男性的年龄和种族差异显著. 这些变化会影响能量代谢和脂肪酸生物合成,强调需要在健康研究中考虑种族.
科学领域:
- 代谢学 代谢学 代谢学
- 人体生理学 人体生理学
- 生物化学 生物化学
背景情况:
- 老年男性的特定种族代谢变异在病例控制设置之外没有得到充分研究.
- 了解这些差异对于开发量身定制的治疗方法和理解年龄代谢相互作用至关重要.
研究的目的:
- 使用代谢学方法,对不同种族的中年和老年男性的血清代谢组进行分析.
- 在社区居住的男性中识别特定于年龄和种族的代谢特征.
主要方法:
- 来自572名男性的血清样本 (白人欧洲人,南亚人,非洲人-加勒比人;年龄在40-86岁) 用液体染色学-气体染色学与高分辨率质谱学 (LC-MS/GC-MS) 结合分析.
- 部分最小平方区分分析 (PLS-DA) 模型是为分类而构建的.
- 代谢物被注释,预测变量重要性 (VIP) 评分确定了用于途径丰富分析的关键特征.
主要成果:
- 在种族 (90.53% LC-MS, 85.58% GC-MS) 和年龄 (90.20% LC-MS, 71.13% GC-MS) 方面实现了高分类率.
- 关键的区分特征包括脂质 (脂肪酸,甘油脂,类固醇),有机酸和氨基酸衍生物.
- 途径分析显示了能量代谢 (TCA循环),N-甘氨酸和不和脂肪酸生物合成的显著干扰.
结论:
- 在健康男性中,血清代谢概况显示出与种族和年龄相关的明显差异.
- 在以人口为基础的代谢分析研究中,必须考虑种族驱动的代谢变异,以避免混的解释.
- 代谢途径的解释,特别是能量代谢和脂肪酸生物合成,需要仔细考虑参与者的种族背景.
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