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Updated: Jun 5, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

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儿科急性淋巴细胞白血病中CDKN2A/2B基因的临床特征和预后分析:一个回顾性病例控制研究

Shi-Mei Huang1, Hui-Qin Chen2, Li-Ting Liu2

  • 1Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.

Hematology (Amsterdam, Netherlands)
|December 16, 2024
PubMed
概括

患有CDKN2A/2B基因缺失的儿科急性淋巴细胞白血病 (ALL) 患者表现出明显的临床特征,但对整体存活率没有显著影响. 这一组的肝积病表明预后较差,突出显示了风险分层的必要性.

关键词:
CDKN2A/2B 基因删除 基因删除儿科所有 儿科所有临床特征 临床特征预后分析 预后分析

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The Retinoblastoma Gene

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The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
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