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肌肉PGC-1α过度表达驱动代谢物分泌增强皮下脂肪细胞棕色化

Caterina Miro¹, Ciro Menale¹, Lucia Acampora¹

¹Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.

Journal of cellular physiology

|December 16, 2024

概括

肌肉中的氧酶增殖器激活受体-γ联合激活器-1α (PGC-1α) 激活线粒体,改变代谢物. 这些变化影响脂肪组织 (AT) 细胞分化和色,特别是在皮下AT细胞中.

科学领域:

骨肌肉和脂肪组织之间的代谢相互作用.
线粒体生物发生和功能调节.
内分泌和代谢信号通路.

背景情况:

肌肉和脂肪组织通过内分泌和生化信号进行通信.
越来越多地认识到一种涉及组织之间信号代谢物的代谢网络.
过氧酶增殖器激活的受体-γ联合激活剂-1α (PGC-1α) 是肌肉中线粒体生物发生的主调节者,促进转向氧化肌纤维.

研究的目的:

调查肌肉纤维过度表达PGC-1α的代谢物分泌特征.
为了确定PGC-1α诱导的代谢变化对脂肪组织的影响.
阐明由肌肉衍生代谢物影响脂肪组织功能的机制.

主要方法:

使用一种肌肉特定的PGC-1α过度表达的小鼠模型 (MCK-PGC-1α).
使用核磁共振 (NMR) 分析了血清和肌肉培养介质代谢物概况.
评估了改变代谢物对脂肪细胞分化和棕色化 in vitro 和 in vivo 的影响.

主要成果:

揭示了MCK-PGC-1α肌肉纤维中各种代谢物的修饰水平,表明代谢激活.
证明失调的代谢物水平影响了脂肪细胞分化和脂肪组织色.
与内脏WAT相比,观察到对皮下白色脂肪组织 (WAT) 的恶化影响.

结论:

证实了PGC-1α在触发骨肌肉中的线粒体功能中的作用.
提出了PGC-1α在调节肌肉代谢物产生的新功能.
突出了PGC-1α对脂肪组织激活和通过代谢信号的色的影响.

关键词:

在PGC-1α中.脂肪细胞 (adipocytes) 是一种脂肪细胞.布朗宁是一个布朗宁.代谢产物的代谢产物这是骨肌肉的骨架肌肉.

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