工业融资本身并不是因为存在偏见风险而降低研究评级的原因
João Pedro Lima1, Arnav Agarwal1,2,3, Gordon H Guyatt1,2,3
1DEPARTMENT OF HEALTH RESEARCH METHODS, EVIDENCE AND IMPACT, MCMASTER UNIVERSITY, HAMILTON, ONTARIO, CANADA.
概括
医疗研究中的行业资金影响研究设计和结果. 由行业资助的随机对照试验 (RCT) 显示了更高的盲目化和引用率,但样本规模更小,结果更为积极.
科学领域:
- 医学研究方法论医学研究方法论.
- 临床试验分析临床试验分析
- 出版偏见研究研究出版偏见研究.
背景情况:
- 工业融资在医学研究中普遍存在,这引发了对其对研究设计和结果的影响的问题.
- 了解行业资助研究的特点对于解释研究结果和确保科学完整性至关重要.
研究的目的:
- 系统地比较随机对照试验 (RCT) 的研究特征和方法方面,基于行业资金的存在或不存在.
- 确定行业资助的研究如何进行和报告的潜在偏见或差异.
主要方法:
- 进行了在三个主要医学期刊上发表的随机对照试验 (RCT) 的系统调查.
- 研究的特点和方法方面比较了行业资助和非行业资助的试验.
主要成果:
- 工业资助的RCT更有可能被蒙蔽,并在clinicaltrials.gov.gov上发布结果.
- 这些试验也产生了更高的引用数量.
- 相反,由行业资助的试验具有较小的样本规模,更频繁地使用安慰剂比较剂,以及代用初级结果.
- 更多的行业资助的试验报告了积极的结果.
结论:
- 产业融资与RCT中的特定方法选择和报告模式有关.
- 这些差异可能会影响行业赞助的研究的感知成功和影响.
- 需要进一步研究这些发现对基于证据的医学的影响.
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