同时分析食品中残留的禁用兴奋剂物质,使用气色谱-双重质谱法
Yejin Lee1,2, Yoeseph Cho1, Seongeun Jeon1
1Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea. son.junghyun@kist.re.kr.
Analytical methods : advancing methods and applications
|December 16, 2024
概括
一种新方法可以检测食品中的禁用兴奋剂物质,确保食品的安全. 这项分析发现肉中有一些荷尔蒙,但低于限度,有助于防止意外的兴奋剂使用.
科学领域:
- 食品安全 食品安全
- 分析化学 分析化学
- 法医科学 法医科学 法医科学
背景情况:
- 不断食用各种食物会导致意外接触残留污染物的风险.
- 改善前期监测程序对于确保食品安全至关重要.
- 禁止的兴奋剂物质可以不经意间通过食物被摄入.
研究的目的:
- 开发一种快速有效的检测方法,用于监测食品中的残留污染物,特别是禁止使用的兴奋剂.
- 建立一种可靠的方法,同时选多种兴奋剂化合物.
- 评估潜在的食物中的激素暴露水平,并支持食品安全.
主要方法:
- 选择了73种兴奋剂化合物,包括类合成剂.
- 开发一种使用气体染色学-并联质谱法 (GC-MS/MS) 的同时选方法.
- 基于GC-MS/MS食品矩阵特征的样本准备模块的优化.
- 使用代表性食品矩阵验证分析方法.
主要成果:
- 开发的GC-MS/MS方法取得了良好的回收率 (80-123%),量化极限为0.01-20μg kg-1.1.
- 分析了40个商业食品样本,包括肉类,使用既定方法进行了分析.
- 在肉样品中检测到的内源性激素 (,纳德罗龙,19-诺兰德罗,19-诺雷西奥科拉诺) 低于最大残留物限值.
结论:
- 开发的试验有效监测食品中的残留兴奋剂物质.
- 该方法可以评估潜在的食物内源性激素的暴露.
- 这种方法提高了食品安全,并有助于预防运动员的无意中兴奋剂事件.
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