静态负荷对中风后长期生存的影响
Nicole Betty Johnson1, Erica M Jones2, Bruce Ovbiagele3
1Department of Neurology, Harbor UCLA Medical Center, Torrance, CA (N.B.J.).
Stroke
|December 16, 2024
概括
更高的静态负荷指数 (ALI),衡量生理压力的指标,与死亡率的增加有关. 这包括中风幸存者的全因和心血管死亡率以及普通人群中风死亡率.
科学领域:
- 生理学 生理学 生理学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 静态负荷指数 (ALI) 量化了对慢性压力的生理反应.
- 了解ALI对死亡率的影响对于公共卫生干预至关重要.
研究的目的:
- 评估ALI与所有原因,心血管和中风死亡率之间的关联.
- 为了检查这些协会在个人中风史和一般人群.
主要方法:
- 利用了来自国家健康和营养检查调查 (NHANES III,1988-1994) 和2015年链接死亡率文件的数据.
- 采用Cox的比例危险模型来分析死亡率结果,以多个共同变量进行调整.
- 针对全国代表性估计的计算ALI流行率的加权值.
主要成果:
- 与先前中风组中ALI ≤1的人相比,ALI ≥3的个体具有显著更高的调整全因 (HR,2.7) 和心血管死亡率 (HR,4.5).
- 在一般的NHANES人群中,ALI ≥3与调整后的中风死亡率高出1.8倍有关.
- 更高的ALI与年龄较大,黑人和墨西哥裔美国人种族以及多种并发症有关.
结论:
- 升高的ALI是中风幸存者中全因和心血管死亡率增加的重要预测因素.
- 更高的ALI也与一般人群中中风死亡率的增加有关.
- 这些发现凸显了ALI在不同人群中的预后价值.
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