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Updated: Jun 5, 2025

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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Published on: September 8, 2012

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在II型和V型CRISPR-Cas系统中,DNA标结合诱导的crRNA前处理

Jiyun Chen1, Xiaofeng Lin1, Wenwen Xiang1

  • 1State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, No. 4221, Xiang'an South Road, Xiamen 361102, China.

Nucleic acids research
|December 16, 2024
PubMed
概括

结合DNA标激活了Cas12a和Cas9等CRISPR-Cas酶,以切割前体CRISPRRNA (前crRNA) 间隔器. 这一发现使得一种简单,敏感和特定的一步DNA检测方法成为可能.

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