来自内性真菌的抗疟疾和抗微生物物质Chaetomium globosum BCC7187676
Nantiya Bunbamrung1, Chakapong Intaraudom1, Aibrohim Dramae1
1National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand.
Natural product research
|December 16, 2024
概括
内生菌Chaetomium globosum产生了具有显著抗疟疾和抗结核活性的新型化合物. 这些天然产品对低细胞毒性药物发现有前途.
科学领域:
- 自然产品化学 自然产品化学
- 药用化学 医学化学
- 菌类学 菌类学是指菌类学.
背景情况:
- 植物性真菌是生物活性天然产品的丰富来源.
- 众所周知,Chaetomium globosum可以产生各种不同的二次代谢产物.
- 研究真菌内细胞可以导致发现新的治疗剂.
研究的目的:
- 从内菌Chaetomium globosum BCC71876.6中分离和描述化合物.
- 评估分离化合物的生物活性,包括抗疟疾,抗结核病,抗植物病原菌,抗菌和细胞毒性.
主要方法:
- 使用色谱技术分离和净化化合物.
- 使用核磁共振 (NMR) 光谱学阐明结构,并与文献数据进行比较.
- 在体外评估对各种细胞系和病原体的生物活性.
主要成果:
- 分离了三个新的化合物 (1,2,17) 和十五个已知的化合物 (3-16,18).
- 化合物表现出广泛的生物活性,细胞毒性低.
- 化合物5 (cochliodinol) 显示出强大的抗疟疾活性 (IC50 4.39 μM).
- 化合物11 (chaetomugilin J) 显示出强烈的抗结核活性 (MIC 3.13μg/mL).
结论:
- Chaetomium globosum BCC71876是一种生物活性天然产品的丰富来源.
- 分离出来的化合物,特别是可克里奥迪诺和沙特穆吉林J,有可能作为抗疟疾药物和抗结核病药物开发.
- 对这些化合物的进一步研究可能会导致新的治疗策略.
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