经批准的和新兴的基于激素的抗肥胖药物:一篇评论文章
Wael R Sidrak1, Sanjay Kalra2, Atul Kalhan3
1Department of Endocrinology and Diabetes, Abou-Seifein Diabetes and Endocrine Center, Cairo, Egypt.
Indian journal of endocrinology and metabolism
|December 16, 2024
概括
下一代抗肥胖药物 (AOMs) 针对肠-大脑通信,特别是类似葡萄糖-1受体激动剂 (GLP1RAs),显示显著减肥. 新兴的基于激素的AOM提供了多样化的选择,但长期安全性数据尚未公布.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 代谢疾病 代谢疾病
背景情况:
- 肥胖是一种复杂的慢性疾病,对全球健康有影响.
- 了解肠-大脑信号的进步刺激了新型抗肥胖药物 (AOM) 的开发.
- 基于激素的AOMs,特别是那些针对葡萄糖类-1受体 (GLP1R) 的AOMs,处于治疗创新的最前沿.
研究的目的:
- 为批准的和新兴的基于激素的AOM提供全面的概述.
- 突出目前和研究中的AOMs的分子机制和临床疗效.
- 讨论肥胖药物治疗的潜在未来景观.
主要方法:
- 对已批准和正在研究的AOM进行临床试验数据的审查.
- 对向GLP1R,氨酸受体和双/三激动因子通路的药物的分析.
- 综合关于减肥功效和作用机制的信息.
主要成果:
- 已批准的GLP1受体激动剂 (GLP1RAs),如利拉格卢提德和塞马格卢提德,是已知的治疗方法.
- 新兴药物包括口服GLP1RAs (赛马格卢提德,达努格利,奥福格利),氨酸受体激活剂 (卡格利林提德),双GIP/GLP-1激活剂 (蒂尔泽帕提德) 和GLP1R/GCGR双激活剂 (苏尔沃杜提德,马兹杜提德,佩维杜提德) 显示显著体重减轻.
- 一种GLP1R/GCGR/GIPR三抗剂 (Retatrutide) 在第二阶段试验中显示显著减肥.
结论:
- 一系列基于激素的AOM正在开发中,为肥胖提供了有前途的治疗选择.
- GLP1RAs和多抗激素疗法代表了肥胖药物治疗的重大进步.
- 需要进一步的研究来确定这些新药的长期安全性和心血管益处.
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