在复发性多发性硬化症中映射认知功能障碍与轻度残疾:来自南印度的横截面研究
Sruthi S Nair1, Jissa Vinodha Thulaseedharan2, Neenumol Kandagathparambil Rajan2
1Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
Multiple sclerosis journal - experimental, translational and clinical
|December 16, 2024
概括
认知功能障碍在早期多发性硬化症 (MS) 中很常见. 一个经过区域调整的电池发现印度患有复发性多发性硬化症的患者的处理速度,记忆和执行功能显著受损.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 心理学 心理学 心理学
背景情况:
- 认知功能障碍是多发性硬化症 (MS) 的早期和常见症状.
- 在印度,针对多发性硬化症患者的本地适应的神经心理数据很少.
- 了解不同人群中的认知模式对于有效的MS管理至关重要.
研究的目的:
- 为了确定印度患有复发性多发性硬化 (RMS) 和轻度残疾的患者认知障碍的模式.
- 为了利用一个区域适应的,MS特定的认知评估电池.
- 为了比较患有MS (pwMS) 的人与健康对照人之间的认知表现.
主要方法:
- 评估了59个pwMS (扩展残疾状况尺度[EDSS]≤4) 和62个对照组的队列.
- 采用了8个神经心理测试的电池,测量了11个认知功能.
- 认知测试得分在各组之间进行了比较,以确定损伤的模式和关联.
主要成果:
- 患有多发性硬化症的人在11项认知指标中的10项表现明显差于对照组.
- 在节奏听力序列加法测试 (PASAT),符号数字模式测试 (SDMT),口语流利 (VF) 和Trail Making Test-B (TMT-B) 中观察到损伤的最大效果大小.
- 认知障碍,定义为两个或两个以上异常测试的表现,在69.5%的pwMS中存在,男性性别是重要的相关因素.
结论:
- 近三分之二的MS和轻度残疾患者表现出认知异常.
- 主要受影响的领域包括处理速度,工作记忆,执行功能和口语流性.
- 这些发现强调了MS中认知缺陷的早期和广泛性质,即使是轻度残疾.
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