SIRT1与炎症之间的关系:系统性审查和元分析
Haiyang Sun1, Dong Li1, Chaojie Wei1
1Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Frontiers in immunology
|December 16, 2024
概括
炎症通常会增加SIRT1 (静音交配类型信息调节2同类1) 水平,但这取决于年龄和病情. 需要进一步的研究来了解它在疾病进展中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 生物化学 生化学
背景情况:
- 已知SIRT1的抗炎功能 (静音交配类型信息规则2同类1),但在炎症条件下其表达水平尚不清楚.
- 了解SIRT1在炎症中的作用对于阐明其参与各种免疫生物过程和疾病病原性至关重要.
研究的目的:
- 通过全面的元分析,系统地评估SIRT1水平和炎症状态之间的关系.
- 综合现有证据,以澄清围绕SIRT1表达在炎症背景下的模两可.
主要方法:
- 在三大数据库中进行了系统的文献搜索,搜索到2024年3月之前发表的研究.
- 采用随机效应模型对来自13个出版物 (21个数据集,2,028名参与者) 的数据进行了元分析,包括横截面和纵向研究.
- 计算了加权平均差异 (WMDs),并进行了子组,灵敏度和偏差分析.
主要成果:
- 分析显示,与对照组相比,炎症组的SIRT1水平在预调整 (WMD:3.18 ng/ml) 和后调整 (WMD:0.88 ng/ml) 期间显著更高.
- 亚组分析表明,中年炎症患者的SIRT1水平较低 (WMD: -0.85 ng/ml).
- 在涉及东亚人口,血样本,自身免疫性疾病和肌肉骨疾病的研究中观察到较高的SIRT1水平.
结论:
- 这些发现表明,SIRT1在应对炎症时的总体上调,突出了它在免疫系统调节中的潜在作用.
- 显著的异质性,部分是由于横截面数据的优势,限制了关于SIRT1在疾病进展过程中的动态的最终结论.
- 需要进一步的纵向研究,以充分理解SIRT1表达和炎症疾病轨迹之间的时间关系.
更多相关视频
12:50Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
6.5K
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
377
相关概念视频
The JAK-STAT Signaling Pathway
8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.7K
NF-κB-dependent Signaling Pathway
7.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.2K
Inflammatory Response
1.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.8K
Regulation of the Unfolded Protein Response
2.4K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.4K
Inflammation
52.5K
Overview
52.5K
T Cell Types and Functions
947
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
947
