叶酸间接的Mg/Al分层双氧化物 - 一个多功能纳米混合输送系统用于局部应用
Phumelele Kleyi1, Vusani Mandiwana1, Marinda de Beer1
1Centre for Nanostructured and Advanced Materials, DSI-CSIR Nanotechnology Innovation Centre, Council for Scientific and Industrial Research, Pretoria 0001, South Africa.
ACS omega
|December 16, 2024
概括
研究人员开发了一种新型纳米混合体,使用分层双氧化物 (LDHs) 来在护肤中提供叶酸 (FA). 这种LDH-FA纳米混合增强局部配方的稳定性,并有效地通过皮肤传递FA.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 皮肤病学 皮肤病学
背景情况:
- 皮肤的屏障功能限制了活性分子的局部传递.
- 纳米技术为增强透皮传递提供了解决方案.
- 层状双氧化物 (LDHs) 是用于药物输送的有希望的纳米材料.
研究的目的:
- 为局部应用开发和表征叶酸 (FA) 间接的LDH纳米混合体.
- 为了评估FA-LDH纳米混合物的物理化学和生物特性,在一个油在水乳液中.
- 评估来自纳米混合配方的FA的受控释放和通过皮肤透.
主要方法:
- 合成Mg/Al LDH与FA交叠的共同沉方法.
- 使用X射线衍射 (XRD) 和富里埃变换红外光谱 (FTIR) 进行了表征.
- 一种含有FA-LDH纳米混合物的油在水乳液的配方.
- 在体外释放研究,学分析,细胞毒性测定 (HaCaT细胞) 和透皮透实验 (弗朗兹扩散细胞).
主要成果:
- XRD和FTIR证实了FA成功插入LDH中间层.
- 该FA-LDH纳米混合体表现出与自由FA相比的抗氧化活性.
- 使用纳米混合物的配方显示出改善的质性质 (流动行为,产量压力,储存模量).
- 在HaCaT细胞中没有观察到细胞毒性.
- 实验室研究表明,依赖于pH的受控释放和有效的FA的通过皮肤透.
结论:
- FA-LDH纳米混合是一种稳定且有效的载体,用于局部FA的输送.
- 纳米混合增强了护肤配方的稳定性和质量.
- 这种纳米混合体显示出作为局部应用的多功能活性成分的巨大潜力.
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