功能性内镜手术后非类固醇抗炎药物引起的出血风险:TrinetX数据库分析
Mandy K Salmon1, Jacob G Eide2, Rijul S Kshirsagar3
1Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA.
World journal of otorhinolaryngology - head and neck surgery
|December 16, 2024
概括
非类固醇抗炎药物 (NSAIDs) 是功能内镜鼻手术 (FESS) 后的一种安全的术后疼痛管理选择. 在FESS之前继续服用阿司匹林的患者面临术后出血的风险增加,特别是表.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 外科手术的结果
- 药理学 药理学是指药理学的学科.
背景情况:
- 功能性内镜外科手术 (FESS) 后的术后疼痛管理需要仔细考虑出血风险,特别是关于阿司匹林的使用.
- 关于在FESS之前无法停止服用阿司匹林的患者出血风险的数据有限.
研究的目的:
- 为了比较使用非类固醇抗炎药物 (NSAIDs) 和阿片类药物管理的FESS患者的术后出血并发症.
- 为了确定在FESS之前继续服用阿司匹林治疗的患者与停止服用阿司匹林治疗的患者间的表发生率.
主要方法:
- 对接受FESS的患者的TrinetX数据库的回顾性分析.
- 倾向匹配被用来比较NSAID和阿片类药物组之间的结果,以及阿司匹林使用者和非使用者之间的结果.
主要成果:
- 在FESS后的NSAID和阿片类药物组之间没有发现表症几率的显著差异 (OR: 1.32,95%CI: 0.90-1.94).
- 在FESS之前继续服用阿司匹林的患者表现出较高的出血率 (14.67%) 与停止服用阿司匹林 (9.00%) 的患者相比 (OR: 1.74,95% CI: 1.20-2.51).
- 7.67%的NSAID组患者需要救援阿片类药物.
结论:
- 在没有先前存在出血风险的FESS患者中,NSAID使用是阿片类药物用于术后疼痛管理的安全替代品.
- 在FESS前一周继续服用阿司匹林治疗与术后表症的风险增加有关.
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