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Disorders of Leukocytes01:27

Disorders of Leukocytes

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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扩散大B细胞淋巴瘤呈现高热血症

Yasser Hegazy1, Mike Chung2, Nicholas Zamora2

  • 1Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York, USA.

Cureus
|December 16, 2024
PubMed
概括
此摘要是机器生成的。

本病例报告详细介绍了一种罕见的B型大细胞淋巴瘤 (DLBCL) 超血症病例,该病例是由异胎维生素D的产生引起的. 这一发现突显了DLBCL患者中不常见的机制和潜在的预后影响.

关键词:
1,25-二氧维生素d是25-二氧维生素d的组成部分.扩散型大B细胞淋巴瘤 (DLBCL)过高血症的情况.与恶性瘤相关的高血症.非霍奇金淋巴瘤非霍奇金淋巴瘤

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科学领域:

  • 在瘤学瘤学.
  • 内分泌学 在内分泌学.
  • 代谢并发症 代谢并发症

背景情况:

  • 高热血症是固体瘤的常见并发症,但在血液性恶性瘤中很少见,例如扩散性大B细胞淋巴瘤 (DLBCL).
  • 淋巴瘤相关高热血症的常见原因包括甲状腺类激素相关分泌 (PTHrP).
  • 不太常见的机制涉及通过1-α-基酶活性产生的1,25-二氧维生素D (1,25(OH) 2D) 的异位产量.

研究的目的:

  • 在DLBCL中报告一种超血病病例,该病例归因于异位1,25(OH) 2D生产.
  • 调查这种罕见表现的诊断途径和病理生理学.
  • 讨论DLBCL中高血症的潜在预后意义.

主要方法:

  • 一个60岁的女性患有偶发高血病的病例报告.
  • 实验室评价,包括,甲状腺上腺激素 (PTH) 和1,25(OH) 2D水平.
  • 图像 (肝脏和脏质量) 和肝脏活检用于DLBCL诊断.
  • 排除常见的高血症病因 (骨解转移,PTHrP).

主要成果:

  • 诊断DLBCL与肝脏和脏的参与.
  • 临界高血症 (12.5 mg/dL) 与抑制的PTH和升高的1,25(OH) 2D水平.
  • 宫外1,25(OH) 2D的产生被证实是可能的原因,排除了其他机制.
  • 超血症可能表明DLBCL的侵袭性疾病和不良预后.

结论:

  • 在DLBCL中高血症可能是由于罕见的机制,如异位1,25(OH) 2D合成.
  • 这一案例凸显了考虑DLBCL高血症的替代病理生理学的重要性.
  • 高血症可能作为激进DLBCL的生物标志物,需要进一步研究其预后价值.