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维生素D和非痴呆症的PD中的焦点脑缩:一个VBM研究

Yingying Xu¹, Erlei Wang², Qilin Zhang¹

¹Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Frontiers in human neuroscience

|December 16, 2024

概括

在帕金森病患者中降低维生素D水平.

科学领域:

神经科学是一个神经科学.
内分泌学在内分泌学.
放射学放射学是一门学科.

背景情况:

维生素D的状态与认知功能有关.
灰质体积 (GMV) 可能表明认知健康.
调查维生素D与在没有痴呆症 (PDND) 的帕金森病中大脑结构之间的联系.

研究的目的:

为了确定较低的血清25-基维生素D水平与PDND患者的脑GMV降低是否相关.
在PDND中探索维生素D,认知和大脑结构之间的关系.

主要方法:

在24名PDND患者和24名健康对照者 (HCs) 中比较了血清25-氧维生素D水平和认知表现.
在MRI数据上使用基于voxel的形态测量 (VBM) 来评估GMV.
进行回归分析以评估关联.

主要成果:

PDND患者的血清25-基维生素D水平明显低于HC患者.
维生素D水平与认知测试 (Trail Making Test-A,符号数字模式测试,听觉口头学习测试) 的表现存在相关性.
在右状转移GMV和血清25-氧维生素D水平之间发现了正相关性.

结论:

较低的维生素D可能会降低PDND中的右状回环GMV.
这种减少可能会损害听觉语言学习和空间认知.
在PDND中,维生素D缺乏,大脑结构变化和认知衰退之间的潜在联系.

关键词:

帕金森病是帕金森氏症的一种疾病.认知认知认知灰色物质的体积,灰色物质的体积.维生素D是维生素D的重要组成部分.基于voxel的形态测量方法

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