坚持生活必需品8与延迟白质衰老有关
medRxiv : the preprint server for health sciences
|December 16, 2024
概括
坚持生命的基本8 (LE8) 促进更健康的大脑衰老,降低痴呆症的风险. 生活方式因素显著影响大脑年龄,其影响因遗传倾向而受到缓解,特别是APOE4等位基因.
科学领域:
- 神经科学是一个神经科学.
- 心血管健康 心血管健康
- 遗传学 遗传学 是一个
背景情况:
- 美国心脏协会的生命必需品8 (LE8) 为心血管健康提供了一个框架.
- 对于LE8对健康大脑衰老的影响及其与APOE4等遗传风险因素的相互作用仍然不清楚.
- 了解这些关系对于制定减轻痴呆风险的策略至关重要.
研究的目的:
- 调查LE8坚持和白质大脑衰老之间的关联.
- 检查APOE4等位基因对这种关系的缓和作用.
主要方法:
- 使用英国生物库数据进行的横截面研究 (n=18,817).
- 评估的LE8变量 (饮食,活动,睡眠等) 和APOE4的基因型.
- 利用扩散张力成像计算白质脑年龄差距通过随机森林回归.
主要成果:
- 较高的LE8分数与减少白质大脑年龄差距相关,表明大脑衰老延迟.
- 这种关联对于单个LE8组件来说是显著的.
- 与APOE4载体相比,非APOE4载体中LE8的有益作用更为明显.
- 在早期中年妇女中观察到LE8和大脑衰老之间的显著相互作用,这些妇女患有APOE4.4.
结论:
- 坚持LE8与延迟大脑衰老有关,其影响由APOE4基因型调节.
- 生活方式干预措施在降低痴呆风险方面显示出有前途.
- 考虑遗传倾向和性别的个性化预防策略是有必要的.
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