全基因组机器学习分析COVID-19的无氧症和老年症
Lucas Pietan1,2, Elizabeth Phillippi3, Marcelo Melo1,3
1Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA 52242, USA.
medRxiv : the preprint server for health sciences
|December 16, 2024
概括
COVID-19可能会导致长时间的嗅觉 (厌氧) 和味觉 (老年症) 丧失. 这项研究确定了影响这些症状的宿主遗传因素,为COVID-19相关感官损伤的潜在治疗提供了见解.
科学领域:
- 遗传学 是一个遗传学.
- 传染性疾病 传染性疾病
- 神经科学是一个神经科学.
背景情况:
- 由于COVID-19的流行,导致了广泛的健康和社会干扰.
- 嗅觉 (厌氧) 和味觉 (老年症) 的丧失是COVID-19的常见,有时长期的症状.
- 了解这些感官障碍的遗传基础对于开发向治疗至关重要.
研究的目的:
- 调查宿主遗传因素导致COVID-19患者的厌氧症和/或老年症.
- 开发和应用一种新的机器学习管道,用于变体和基因优先级.
- 为了确定与COVID-19引起的感官损失相关的候选基因和变异.
主要方法:
- 利用来自爱荷华大学 (UI) 和我们所有人 (AoU) 研究计划COVID-19队伍的人类基因组测序数据.
- 采用特征选择技术和机器学习来进行患者分类和变异/基因优先排序.
- 使用基于换的变量重要性 (PVI) 和接收器操作特征 (AUROC) 曲线下的面积来评估模型性能.
主要成果:
- 在UI队列中的变异和基因分析 (高达0.798) 和AoU队列中的变异分析 (0.687) 中获得了高AUROC得分.
- 优先考虑了几个涉及免疫,神经元和信号通路的新奇和已知的遗传因素.
- 确定了潜在的宿主遗传贡献者,导致COVID-19相关的厌氧和衰老症.
结论:
- 该研究成功确定了与COVID-19相关的感官障碍相关的候选宿主遗传因素.
- 这些发现支持有关免疫和神经元信号传导在阿诺斯米亚/老年症中的作用的现有假设.
- 这项研究为了解COVID-19的感觉神经元方面以及开发未来治疗策略提供了基础.
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