美国人口的口腔微生物群和全因死亡率
Emily Vogtmann1, Yukiko Yano1, Jianxin Shi1
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
medRxiv : the preprint server for health sciences
|December 16, 2024
概括
口腔微生物群,特别是其多样性和某些细菌属,与死亡风险有关. 更高的口腔微生物群多样性和Bacteroides的存在可能会降低死亡率,而Granulicatella和Lactobacillus可能会增加死亡率.
科学领域:
- 微生物组研究 微生物组研究
- 公共卫生 公共卫生
- 基因组学就是基因组学.
背景情况:
- 糟糕的口腔健康和牙周病与口腔微生物组的改变和死亡率的增加有关.
- 缺乏直接评估口腔微生物组与死亡率相关性的大规模研究.
研究的目的:
- 为了前性地评估口腔微生物组测量和全因死亡率之间的关联.
- 调查口腔细菌群落是否是死亡风险的直接预测因素.
主要方法:
- 利用了2009-2012年国家健康和营养检查调查 (NHANES) 的数据,包括来自7721名参与者的口腔冲洗样本.
- 通过16S rRNA基因测序评估口腔微生物组,分析alpha和beta多样性和属级组成.
- 将参与者数据与国家死亡指数 (NDI) 链接起来,以便在2019年之前对死亡率进行跟踪,使用Cox比例危险回归.
主要成果:
- 较高的连续α多样性 (香农-韦纳指数) 与全因死亡率 (HR=0.85 per SD) 相反相关.
- 特定的β多样性测量 (Bray-Curtis PCoA2,加权UniFrac PCoA1) 也与降低死亡率有显著的关联.
- 较高的Granulicatella和Lactobacillus丰度与较高的死亡风险有关,而较高的Bacteroides丰度与风险降低有关.
结论:
- 口腔微生物群的测量,包括多样性和特定的细菌属,与代表性美国人口的全因死亡率有关.
- 这些发现凸显了口腔细菌群落在整体健康和疾病结果中的潜在作用.
- 口腔微生物组可以作为死亡风险的潜在生物标志物.
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