相关实验视频

Updated: Jun 5, 2025

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

在患有自闭症的儿童中进行便微生物群移植

Youran Li¹, Pei Xiao¹, Hongfang Ding²

¹Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

Neuropsychiatric disease and treatment

|December 16, 2024

概括

便微生物种移植 (FMT) 改善了自闭症谱系障碍 (ASD) 的核心症状,肠道问题和儿童的睡眠问题. 像囊和NJT这样的上胃肠道输送方法比下胃肠道路线更有效和更安全.

科学领域:

儿科胃肠病学儿科胃肠病学
神经发育障碍神经发育障碍
微生物组研究微生物组研究

背景情况:

自闭症谱系障碍 (ASD) 提出了复杂的挑战,包括核心行为,胃肠道 (GI) 和睡眠障碍.
便微生物种移植 (FMT) 是一种新兴的治疗策略,有可能调节肠道微生物群并影响ASD症状.

研究的目的:

评估FMT在改善ASD诊断儿童的核心症状,胃肠道问题和睡眠障碍方面的临床疗效.
为了比较不同FMT输送方法的安全性和有效性:口服囊 (Caps),透视肠道管 (TET) 和鼻管 (NJT).

主要方法:

这是一项单臂前性研究,涉及98名患有自闭症儿童 (平均年龄为7岁).
参与者通过Caps,TET或NJT接受了FMT,在基线,治疗后和8周后期进行评估.
在自闭症行为检查清单 (ABC),儿童自闭症评分表 (CARS),社会响应量表 (SRS),胃肠道症状评分表 (GSRS) 和儿童睡眠障碍量表 (SDSC) 中评估的变化,以及不良事件 (AE).

主要成果:

在治疗后和随访期间,在所有FMT组 (Caps,TET,NJT) 的ASD核心症状,胃肠道症状和睡眠质量中观察到显著改善.
与TET组相比,Caps和NJT组在ABC,CARS和SRS分数中显示出更大的降低.
与Caps和TET组相比,NJT组在SDSC分数中表现出更好的改善,通常轻微的AE的发病率较低.

结论:

FMT是改善ASD儿童核心症状,胃肠道问题和睡眠障碍的有希望的治疗方法.
在这个儿科群体中,上胃肠道输送路径 (Caps,NJT) 似乎比下胃肠道输送路径 (TET) 更加有效和安全.

关键词:

便微生物群移植便微生物群移植自闭症谱系障碍自闭症谱系障碍有效性有效性有效性.

更多相关视频

Murine Fecal Isolation and Microbiota Transplantation

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

相关概念视频

What is Monogastric Digestion?

What is Monogastric Digestion?

The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...