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在Apeltes quadracus中轴向模式的遗传机制

Amy L Herbert^1,2, David Lee¹, Matthew J McCoy³

¹Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, United States.

Evolution letters

|December 16, 2024

概括

在四脊椎杆背的遗传研究显示,染色体6上主要的QTL控制背脊和pterygiophore特征. 发育基因集群的调控变化推动了野生种群的主要形态进化.

科学领域:

进化遗传学的进化遗传学
发育生物学是发展生物学.
进行比较的基因组学.

背景情况:

动物体图的进化变化的遗传基础,特别是轴向模式,在野生种群中仍然基本未被探索.
四脊椎鱼 (Apeltes quadracus) 在自然界中表现出多样化的轴向模式,这使得它们成为研究进化适应的一个有价值的模型.

研究的目的:

为了研究基因架构的基础上在轴向模式特征的野生差异在阿佩尔特斯quadracus.
为了识别与背脊脊柱,基和脊椎数量的变化相关的定量特征位置 (QTL).

主要方法:

使用遗传交叉和量化特征位点 (QTL) 在野生种群中的绘制.
分析背脊数量/长度,pterygiophore数量和脊椎数量 (腹部和尾部) 的表型变异.

主要成果:

染色体6上的主要QTL显著解释了15%-30%的背脊和pterygiophore特征的表型变异.
14号染色体上的二次QTL影响背脊和椎的长度,解释了大约9%的变化.
对于腹部和尾部脊椎数量差异,没有发现显著的QTL.

结论:

染色体6上的HOXDB基因集群中的调控进化是阿佩尔特人背脊和基变异的关键驱动因素.
虽然特定的QTL位置在Apelte和Gasterosteus之间有所不同,但涉及发育基因集群调节变化的保存机制是鱼主要骨进化的基础.

关键词:

霍克斯基因是霍克斯基因的组成部分.在 QTL 映射中使用 QTL 地图.轴向的图案设计轴向的图案设计增强剂是一种增强剂.进化演化演化演化演化演化演化演化四个脊柱的粘性背脊.

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