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Updated: Jun 5, 2025

MISSION esiRNA for RNAi Screening in Mammalian Cells
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在人类中,siRNAs对基因沉默的结构基础

Sucharita Sarkar1,2, Luca F R Gebert1,2, Ian J MacRae1

  • 1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

bioRxiv : the preprint server for biology
|December 16, 2024
PubMed
概括

对人类Argonaute2 (hAgo2) 的结构洞察力揭示了小干扰RNA (siRNA) 如何催化目标mRNA分裂. 破坏siRNA 3'-end结合稳定了 hAgo2,使得基因沉默的详细结构分析成为可能.

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