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Updated: Jun 5, 2025

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
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细胞内口袋形状通过阿片类受体决定了通过阿片类受体的信号有效性

David A Cooper1, Joseph DePaolo-Boisvert1, Stanley A Nicholson2

  • 1Department of Chemistry, Illinois Institute of Technology, Chicago, Illinois 60616, United States.

bioRxiv : the preprint server for biology
|December 16, 2024
PubMed
概括

由于功能选择性,难以预测受体信号强度. 这项研究表明,一个机器学习模型通过分析受体-连接体复合体构造来准确计算G蛋白和阿雷斯通路的信号效率.

关键词:
7 跨膜螺旋接收器接收器激活机制的激活机制功能选择性的功能选择性.G蛋白结合受体的受体是什么信号的有效性 信号的有效性

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