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Updated: Jun 5, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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发现高吞吐量和深入描述cyclin-CDK对接模式

Mihkel Örd1,2, Matthew J Winters3, Mythili S Subbanna3

  • 1University of Cambridge, CRUK Cambridge Institute, Cambridge, UK.

bioRxiv : the preprint server for biology
|December 16, 2024
PubMed
概括

这项研究揭示了环素与标结合的新方法,揭示了比以前知道的更多种类的环素对接模式. 这些发现增强了我们对细胞分裂调节的理解.

关键词:
他们是SLIMs.结合性亲和力是一种结合性亲和力.具有约束性的特异性.循环环是指一个循环环.循环林依赖的激酶.酶对接对接的酶对接激酶激酶的作用是什么酸化的方法是光化.后翻译修改后的修改一个简短的线性图案.

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Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
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