在中间后壁皮质皮质中介性后壁皮质中介尺度的功能架构
Riichiro Hira1,2,3, Leah B Townsend2, Ikuko T Smith4
1Department of Electrical and Computer Engineering, University of California Santa Barbara.
bioRxiv : the preprint server for biology
|December 16, 2024
概括
小鼠的后壁皮质 (PPC) 具有不同的功能模块. 区域A处理姿势和记忆,而区域AM集成了多感官和认知信息.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 系统神经科学 系统神经科学
背景情况:
- 小鼠的后壁皮质 (PPC) 涉及多种功能,如多感官集成,视觉引导行为,工作记忆和姿势控制.
- 然而,对这些功能及其在PPC和更高视觉区域 (HVA) 内的精确定位的全面理解仍然不完整.
研究的目的:
- 研究介质后壁皮层 (PPC) 中不同区域的不同功能角色和皮层通信模式.
- 阐明前中部 (AM) 和前部 (A) HVA对与行为相关的信息处理的具体贡献.
主要方法:
- 在PPC周围的八个皮质区域同时对数千个神经元进行体内成像,使用双光子间距镜.
- 鼠标执行视觉引导和选择历史依赖的任务,同时记录神经元活动.
- 测量尺度相关性分析被用来检查试验间的变异性和区域间的神经元通信.
主要成果:
- 在两个中间PPC区域中确定了明显的,局部的,与行为相关的功能:中间 (AM) HVA和前部 (A) HVA.
- AM HVA神经元对视觉和选择信息都有反应,这表明它在关联这些感觉通道中的作用.
- A HVA神经元表现出用于存储选择历史和表示姿势的顺序动态,与主要体感区域共享波动.
结论:
- 媒体PPC包括两个不同的模块,A区和AM区,每个模块都有独特的沟通策略.
- 区域A是传输与姿势,运动和工作记忆有关的信息的枢纽.
- 区域AM作为多感官和认知集成的关键网站,处理局部衍生信号.
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