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Updated: Jun 5, 2025

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
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通过腺病毒对IRE1α-XBP1信号的动态调制

Yumi Jang1,2, Fred Bunz1

  • 1Department of Radiation Oncology and Molecular Radiation Sciences, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland USA.

bioRxiv : the preprint server for biology
|December 16, 2024
PubMed
概括

腺病毒5型 (HAdV5) 激活了未折叠蛋白反应 (UPR),但阻断了X盒结合蛋白1 (XBP1s) 的产生. 这种逃避策略与p53降解一起,突显了癌细胞中缺陷的抗病毒防御.

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