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Updated: Jun 5, 2025

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OST催化子单元的冗余性使得N-糖化的治疗向成为可能

Marta Baro1, Hojin Lee1, Vanessa Kelley1,2

  • 1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, 06510 USA.

bioRxiv : the preprint server for biology
|December 16, 2024
PubMed
概括

使用像NGI-189这样的寡糖转移酶 (OST) 抑制剂向蛋白质N-糖化,对瘤学有很大的前景. 这种方法在没有引起毒性的肺癌异种移植中有效抑制EGFR,提供了一种新的治疗途径.

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