传染病原体和多肌痛性风湿症:从发表文献的叙事性审查中出现的关键讨论点
Ciro Manzo1, Marco Isetta2, Alberto Castagna3
1Department of Internal and Geriatric Medicine, Azienda Sanitaria Locale Napoli 3 sud, Rheumatologic Outpatient Clinic, Health District No. 59, Naples, Sant'Agnello, Italy.
Reumatologia
|December 16, 2024
概括
多发性肌痛性风湿症 (PMR) 的确切原因尚不清楚,目前的研究表明感染可能起作用,尽管尚未确定确切的联系. 遗传和表观遗传因素可能对PMR发展很重要.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 遗传学 是一个遗传学.
背景情况:
- 多发性肌痛风湿症 (PMR) 的病因目前尚不清楚.
- 最近的报道表明,PMR和2019年冠状病毒病 (COVID-19) 之间的潜在联系,使人们重新对感染作为触发因素的兴趣.
- 巨细胞动脉炎 (GCA) 与PMR在不到20%的病例中同时发生,人们对感染病原体在这种关联中的作用的理解有限.
研究的目的:
- 审查和讨论PMR和传染病原体之间的关系.
- 为了比较只有PMR的患者和PMR和重叠GCA的患者的传染病原体.
主要方法:
- 在Embase和Medline上进行了非系统的文献搜索,使用了"多肌痛类风湿症"和"感染"等术语.
- 扫描了相关论文的参考列表,以进行额外的研究.
- 排除标准包括会议摘要,非同行评审的来源,以及接种疫苗后的PMR.
主要成果:
- 几种传染病因被认为与PMR有关,但尚未确定确切的因果关系.
- 寻找特定的传染病原体似乎停滞不前,遗传和表观遗传因素可能起着重要作用.
- 免疫接种后的PMR需要在方法上与疫苗辅助剂引起的感染后的PMR区分开来.
结论:
- 虽然一些传染病原体理论上可以触发GCA,但它们在孤立的PMR中的作用似乎很小.
- 传染病原体在PMR病因学中的特定作用及其与GCA的关联需要进一步调查.
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