低卡路里和高蛋白饮食对肌肉,骨和骨髓脂肪组织有不同的影响
Beatriz Coimbra Romano1, Iana Mizumukai de Araújo1, Mariana S P Ribeiro2
1Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14.049-900, Brazil.
JBMR plus
|December 16, 2024
概括
在卡路里限制 (CR) 期间的高蛋白饮食使大鼠的肌肉质量受益,但恶化了骨质恶化和大脑髓脂肪增加. 这表明,在CR下,高蛋白质可能不适合骨健康.
科学领域:
- 营养科学 营养科学
- 骨生物学 骨生物学 骨生物学
- 代谢健康 代谢健康
背景情况:
- 众所周知,卡路里限制 (CR) 会影响身体组成和骨健康.
- 在CR期间高蛋白饮食对各种组织的作用尚未完全理解.
研究的目的:
- 研究高蛋白饮食与卡路里限制 (CR) 对大鼠肌肉,脂肪组织,骨和骨髓脂肪组织 (MAT) 的影响.
主要方法:
- 使用了三组Wistar汉诺威老鼠:对照,CR和CR与高蛋白饮食8周.
- 用DXA评估身体组成.
- 股骨分析包括组织形态测量和脂肪细胞估计.
- 通过微计算机断层扫描 (μCT) 分析骨结构.
- 骨髓造血干细胞的骨质细胞生成被评估.
主要成果:
- 高蛋白质加CR组与对照组相比,与脂肪质量相比,较大的瘦肉质量增加.
- 高蛋白饮食没有改善CR诱导的骨质恶化;μCT显示显著的骨质损失.
- 骨髓脂肪和造血干细胞分化成骨质细胞在高蛋白加CR组增加.
结论:
- 虽然在CR条件下高蛋白饮食可以支持肌肉质量,但它似乎会加剧骨的恶化并增加骨髓脂肪.
- 这种饮食策略可能会在卡路里限制期间对骨健康产生负面影响.
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