大脑对休息BOLD网络的有针对性攻击的弹性作为认知储备的衡量标准
Georgette Argiris1, Yaakov Stern1, Christian Habeck1,2
1Cognitive Neuroscience Division, Department of Neurology, Columbia University Irving Medical Center, New York, NY.
Research square
|December 16, 2024
概括
大脑网络的弹性可能充当认知储备机制. 较高的大脑弹性有助于保持认知功能,尽管与年龄相关的大脑变化.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 衰老研究研究 衰老研究
背景情况:
- 认知储备 (CR) 对于理解认知衰老中的个体差异至关重要.
- 需要神经测量来识别CR背后的机制.
- 通过先进的连接组分析,大脑网络完整性越来越容易被测量.
研究的目的:
- 测试网络弹性是否作为CR候选人的功能.
- 调查网络弹性是否会改变健康老年人的大脑和认知变化之间的关系.
- 探索大脑性 (BR) 作为一种潜在的认知性的神经标志物.
主要方法:
- 在纵向队列中使用休息状态fMRI和神经心理测试 (N=100,年龄50-80岁).
- 在连接组数据 (419个节点) 上使用有针对性的攻击方法评估整个大脑网络的弹性.
- 通过最大连接组件 (LCC) 在节点移除后衰变的最坡来定义弹性.
主要成果:
- 大脑弹性 (BR) 缓解了皮层厚度 (CT) 变化对流体推理的影响.
- 具有较高BR的个体对影响认知表现的CT变化敏感度较低.
- 在对基线LCC,人口统计和初始差异进行控制后的发现.
结论:
- 通过有针对性的攻击来衡量网络弹性,是认知储备机制的可行候选者.
- 较高的大脑网络弹性可能使个人能够更好地承受大脑结构变化并保持认知功能.
- 这项研究支持网络弹性作为老龄人口认知弹性的生物标志物的实用性.
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