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构建,验证和可视化基于网络的名图,以预测男性乳腺癌患者的存活率,其前列腺癌是其次原发性癌症

Runsen Du^1,2,3, Fangjian Shang^1,2, Xin Chen^1,2

¹Breast and Thyroid Center, The First Affiliated Hospital of Hebei Medical University, Shijiazhuang, China.

|December 16, 2024

概括

患有第二次原发性前列腺癌 (spPCa) 的男性乳腺癌 (MBC) 幸存者预后比患有其他二次癌症的人更好. 开发的预测性名录图可以帮助MBC患者的个性化治疗决策.

科学领域:

在瘤学瘤学.
癌症流行病学癌症流行病学
生存分析的分析.

背景情况:

男性乳腺癌 (MBC) 幸存者面临第二次原发性恶性瘤 (SPMs) 的风险增加.
第二次原发性前列腺癌 (spPCa) 对MBC幸存者来说是一个重大问题.
研究spPCa在MBC患者的预后影响至关重要.

研究的目的:

评估患有spPCa.的MBC患者的生存结果.
开发和验证SPM的MBC患者的整体生存期 (OS) 和癌症特异性生存期 (CSS) 的预测模型.
为个性化临床管理建立风险分层系统.

主要方法:

对SPM的MBC患者的SEER数据库 (2000-2020) 的回顾性分析.
倾向性得分匹配 (PSM) 以平衡患者的特征.
卡普兰 - 梅尔分析,考克斯回归,以及用于生存预测的诺莫格拉姆开发.
使用C指数,ROC曲线,校准图和DCA进行验证.

主要成果:

总共分析了885名患有SPM的MBC患者;265人 (29.9%) 患有spPCa.
为了进行比较,PSM确定了257对.
与其他SPMs患者相比,患有spPCa的MBC患者表现出明显更好的OS和CSS.
开发的诺米图表显示了对3年,5年,8年和10年的OS和CSS的优异预测性能.
风险分层确定了高风险患者,其生存结果较差.

结论:

患有spPCa的MBC患者通常有更有利的预后.
开发的诺姆图准确预测OS和CSS,有助于临床决策.
风险分层可以帮助确定需要更密切监测和量身定制的治疗策略的患者.

关键词:

男人的乳腺癌 (MBC)监测,流行病学和最终结果 (SEER)这个名字是名ogramogram.第二种原发性前列腺癌 (spPCa)幸存的可能性生存的可能性.

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