相关实验视频

Updated: Jun 5, 2025

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

循环RNA CDR1as/ciRS-7-一种在固体瘤中的新生物标志物

Yun Zhang^1,2, Chanyu Xiong¹, Zhilin Jiang¹

¹Sichuan Provincial Key Laboratory for Human Disease Gene Study, Genome Sequencing Center, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Frontiers in oncology

|December 16, 2024

概括

高CDR1as/ciRS-7表达表明固体瘤的预后不佳,与较大的瘤大小和晚期相对应. 这种循环RNA可以作为各种癌症的关键预后生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

循环RNACDR1as/ciRS-7被认为是各种癌症中的瘤调节剂.
固体瘤中CDR1as/ciRS-7表达的预后意义需要进一步澄清.

研究的目的:

进行更新的元分析,研究CDR1as/ciRS-7表达与实体瘤临床结果之间的关联.

主要方法:

在PubMed,EMBASE,Web of Science和Ovid数据库中进行系统的文献搜索.
为了评估相关性,计算了 95% 置信区间 (CI) 的聚合危险比率 (HRs) 和奇数比率 (ORs).
包括17项研究,包括2017年至2023年期间诊断的2424名患者.

主要成果:

较高的CDR1as/ciRS-7表达预测了12种固体瘤类型 (HR=1.93) 的整体存活率 (OS) 较差.
发现了较大的瘤大小 (OR=2.11),晚期TNM阶段 (OR=2.05),淋巴结转移 (OR=1.74),和远程转移 (OR=2.79) 的显著关联.
分层分析显示了消化和呼吸道癌症的负相关性.

结论:

增加CDR1as/ciRS-7表达与固体瘤的不良临床特征和较短的OS有关.
CDR1as/ciRS-7显示出作为固体瘤独立预后生物标志物的潜力.

关键词:

在CDR1as/ciRS-7中使用.癌症癌症癌症癌症癌症圆形的RNARNA是一个圆形的RNA.这是一个元分析.预后预后预后固体瘤是一种固体瘤.

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...