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益生菌对神经退行性疾病相关症状和系统性炎症的影响:系统性审查
Fengya Zhu1, Shao Yin2, Yuan Wang3
1Traditional Chinese Medicine Department, Zigong First People's Hospital, Zigong, People's Republic of China.
益生菌通过改善症状和减少炎症,对神经退行性疾病 (NDD) 是有前途的. 需要进一步的研究来优化它们在治疗阿尔茨海默氏症和帕金森病等疾病中的使用.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 神经退行性疾病 (NDD) 是一个日益严重的全球健康挑战.
- 益生菌,活的有益微生物,正在研究它们在NDD中的治疗潜力.
- 系统性炎症和氧化应激与各种NDDs的发病有关.
研究的目的:
- 系统地审查和评估益生菌在管理NDD的临床症状中的有效性.
- 评估益生菌对全身炎症和NDD患者抗氧化能力的影响.
- 识别当前研究中的差距,并建议在NDD中进行益生菌干预的未来方向.
主要方法:
- 在主要数据库 (Cochrane Library,Embase,PubMed,Web of Science) 中进行了系统的文献搜索.
- 包括22个随机对照试验 (RCT),重点关注阿尔茨海默病,帕金森病,多发性硬化症和轻度认知障碍.
- 干预时间从4周到16周不等.
主要成果:
- 益生菌在NDD患者的胃肠功能,认知功能,生活质量和心理健康方面有所改善.
- 观察到益生菌在减少全身炎症和增强抗氧化能力方面具有普遍的积极作用.
- 具体的RCT包括:4个用于阿尔茨海默病,10个用于帕金森病,2个用于多发性硬化症,2个用于轻度认知障碍.
结论:
- 目前的证据表明,益生菌对神经退行性疾病具有有前途的治疗潜力.
- 需要进一步进行大规模,高质量的研究,以确定最佳的益生菌菌株,剂量和施用方法.
- 未来的研究应该考虑生活方式和饮食因素,以阐明NDD治疗中的益生菌机制和应用.
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