肝动脉输液化疗在肝细胞癌的当前疗效
Douglas Dias E Silva1, Mitesh Borad2, Pedro Luiz Serrano Uson Junior3
1Department of Oncology, Hospital Israelita Albert Einstein, São Paulo 05652900, Sao Paulo, Brazil.
World journal of gastrointestinal oncology
|December 16, 2024
概括
肝动脉输液化疗 (HAIC) 对于晚期肝细胞癌 (HCC) 是有前途的. 与系统疗法结合HAIC,与单独使用HAIC相比,提供更好的生存结果.
科学领域:
- 肝胆道癌症 肝胆道癌症
- 干预性瘤学干预性瘤学
- 系统性疗法是一种全身疗法.
背景情况:
- 晚期肝细胞癌 (HCC) 治疗正在随着新的全身疗法而发展.
- 结合肝动脉输液化疗 (HAIC) 与全身性药物正在引起人们的注意.
- 评估HAIC和组合疗法对于优化HCC管理至关重要.
研究的目的:
- 进行一个网络元分析,评估HAIC及其组合对高级HCC的疗效和安全性.
- 将基于HAIC的治疗与其他标准疗法进行比较.
- 确定高级HCC的最佳治疗策略.
主要方法:
- 44篇文章的网络元分析.
- 包括关于HAIC,跨动脉化学栓塞,索拉费尼布,伦瓦提尼布,切除,抗PD-1疗法和放射治疗的研究.
- 评估整体生存 (OS),无进展生存 (PFS) 和反应率.
主要成果:
- 在OS,PFS和响应率方面,HAIC表现出优于跨动脉化学栓塞和索拉芬尼的优势.
- 与HAIC单独治疗相比,HAIC与系统性药物 (伦瓦替尼,抗PD-1) 和局部疗法 (切除,放射治疗) 的组合改善了OS和PFS.
- 特定组合显示,在先进的HCC患者中,增强了生存益处.
结论:
- HAIC是晚期HCC的有效治疗方法,性能优于某些传统疗法.
- 涉及HAIC的组合策略显著改善了生存结果.
- 对优化HAIC组合的进一步研究是先进的HCC管理的必要条件.
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