威尔姆斯瘤的环境风险因素:一个系统的审查和元分析
Felix M Onyije1, Roya Dolatkhah1, Ann Olsson1
1Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), 25 avenue Tony Garnier, CS 90627, Lyon Cedex 07 69366, France.
EJC paediatric oncology
|December 16, 2024
概括
这项研究确定了儿童癌症威尔姆斯瘤 (WT) 的关键环境风险因素. 可修改的因素包括父母的农药暴露,而母乳养和叶酸摄入似乎具有保护作用.
科学领域:
- 儿科瘤学 儿科瘤学
- 环境流行病学环境流行病学
- 遗传学和表观遗传学
背景情况:
- 威尔姆斯瘤 (WT) 是儿童癌症死亡的一个重要原因.
- 确定可修改的风险因素对于初级预防策略至关重要.
- 环境暴露越来越多地被认为是导致儿童癌症的潜在因素.
研究的目的:
- 系统地审查和综合与威尔姆斯瘤相关的环境风险因素.
- 进行流行病学研究的元分析,以量化这些关联.
- 为公共卫生倡议提供信息,以预防WT.
主要方法:
- 对病例控制和队列研究进行系统审查和元分析.
- 在PubMed,Web of Science和Embase数据库中搜索了诊断为WT的儿童 (<20岁) 的研究.
- 使用随机效应模型组合相对风险 (RRs) 和95%置信区间 (CI).
主要成果:
- 证实了WT与高出生体重,剖腹产,早产 (<37周) 和高孕年龄之间的关联.
- 父母的职业农药暴露显示WT风险增加 (母亲:RR 1.28,父亲:RR 1.48).
- 对于母乳养和孕妇在怀孕期间摄入叶酸/维生素所观察到的不良关联 (保护作用).
结论:
- 威尔姆斯瘤的可修改风险因素包括父母的职业农药暴露,母乳养和叶酸摄入.
- 虽然协会存在,但它们的力量似乎是温和的.
- 进一步研究环境对WT发展的影响是有必要的.
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