持续眼内压升高的评估 跨抗眼内皮生长因子代理人
Neil A Rana1, Meghana Chalasani2, Jonathan Markle3
1Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Journal of vitreoretinal diseases
|December 16, 2024
概括
虽然大多数抗VEGF药物是安全的,但bevacizumab注射可能会增加持续眼内压力 (IOP) 升高的风险. 需要进一步的研究来了解对IOP和玻璃眼的长期影响.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
背景情况:
- 眼内压力 (IOP) 的升高是青光眼的危险因素.
- 抗血管内皮生长因子 (anti-VEGF) 药物广泛用于治疗视网膜疾病.
- 抗VEGF剂对持续的内血压升高的影响需要进一步研究.
研究的目的:
- 评估不同抗VEGF剂对持续眼内压升高 (IOP) 的发展的影响.
- 为了比较抗VEGF治疗的眼睛和对照眼睛之间IOP升高和绿眼病进展的发生率.
主要方法:
- 一个单一中心的回顾性队列研究包括从2012年到2022年的1604只眼睛 (907个治疗,697个对照).
- 患者接受了贝瓦西祖马布,拉尼祖马布或阿弗利塞普特注射,用于治疗各种视网膜疾病.
- 眼内压力 (IOP) 趋势在治疗开始后的一年内被监测.
主要成果:
- 总的来说,与对照组相比,用抗VEGF治疗的眼睛没有显示持续IOP升高或绿眼病进展的增加率.
- 然而,接受贝瓦西祖马布治疗的眼睛显示,内血压升高的发生率显著更高 (RR, 1.81).
- 持续升高内膜压力的平均注射次数为5.4次,并且在不同药物之间没有显著差异.
结论:
- 与其他研究的抗VEGF药物不同,贝瓦齐祖马布与持续眼内压力 (IOP) 升高的风险增加有关.
- 与其他抗VEGF疗法相比,需要进一步的研究来调查贝瓦西祖马布对长期IOP和玻璃眼的影响.
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