相关实验视频

Updated: Jun 5, 2025

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

与CSVD相关的认知障碍中大脑结构异常的转录模式

Haixia Mao¹, Min Xu¹, Hui Wang^2,3

¹Department of Radiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.

Frontiers in aging neuroscience

|December 16, 2024

概括

与认知障碍相关的小脑血管疾病 (CSVD) 显示大脑缩,特别是在叶. 分子分析揭示了与这些结构变化相关的1580个基因,这表明了多基因机制.

科学领域:

神经成像是一种神经成像.
基因组学就是基因组学.
神经学神经学

背景情况:

小脑血管疾病 (CSVD) 与认知障碍有关.
与CSVD相关的认知障碍中区域大脑脆弱性的分子基础尚不清楚.

研究的目的:

通过基于voxel的形态学 (VBM) 来研究CSVD相关认知障碍中的大脑结构变化.
探索皮层形态和基因表达特征在CSVD相关的认知障碍之间的关系.

主要方法:

使用VBM分析了46名CSVD患者和73名对照组的结构性MRI数据.
用艾伦人类大脑图谱 (Allen Human Brain Atlas) 进行了转录组神经成像相关性分析.

主要成果:

显著的灰质体积 (GMV) 减少被观察到在叶和丘脑,特别是海马,在CSVD患者.
与记忆和执行功能缺陷相关的GMV变化.
1,580个基因与区域GMV变化有显著的关联,富含RNA聚合酶II和轴突生成等途径.

结论:

与CSVD相关的认知障碍中的大脑形态异常与复杂的多基因分子变化有关.
这些发现突出了CSVD病理生理学中遗传因素和结构变化之间的相互作用.

关键词:

艾伦人类大脑亚特拉认知障碍是一种认知障碍.灰色物质的体积,灰色物质的体积.小型脑血管疾病是什么?皮层下血管认知障碍皮层下血管认知障碍转录转录是一种转录.

更多相关视频

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

相关概念视频

Biological Causes of Schizophrenia

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...