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胎儿对母体脂肪酸的依赖:在人类怀孕中进行的一项试点研究,使用C的自然丰度变化¹³C

Simonato Manuela^1,2, Verlato Giovanna¹, Visentin Silvia¹

¹Department of Women's and Children's Health, University of Padova, Padova, Italy.

The British journal of nutrition

|December 16, 2024

概括

人类胎儿在很大程度上依赖于母体脂肪酸 (FA),特别是DHA,因为自我合成有限. 孕产妇的营养和胎盘健康对胎儿发育至关重要.

科学领域:

生物化学生物化学
人体生理学人体生理学
营养科学营养科学

背景情况:

人类胎儿*de novo*脂肪酸 (FA) 生物合成的程度在很大程度上是未知的.
了解胎儿的FA代谢对于评估怀孕期间的营养需求至关重要.

研究的目的:

研究人类胎儿中非必需的FA和内源性长链多不和FA (PUFA) 的新生生物合成.
确定胎儿对母体提供FA的依赖程度,特别是多可沙赫萨酸 (DHA).

主要方法:

利用稳定同位素比质谱法 (IRMS) 测量39对母胎脂体的血中碳同位素比 (δ13C).
在母体和带血液中分析了关键FA (C16:0,C18:0,C18:1n-9,C18:2n-6,C20:4n-6,C22:6n-3) 的δC值.
在母亲和胎儿之间比较了FA δ 13 C值,并评估了母体DHA补充剂 (藻类与鱼油) 对胎儿FA概况的影响.

主要成果:

观察到母亲和胎儿之间所有测量的FA的δ13C值之间存在强烈的线性相关性 (r > 0.80).
在母体和胎儿血之间没有发现FA δ ¹³C值的显著差异,这表明胎儿*de novo*FA合成最小.
与鱼油或没有补充剂相比,母体用藻类DHA补充剂导致血脂中的DHA δ ¹³ C值显著降低.

结论:

人类胎儿对母体血FA,特别是DHA的胎盘转移严重依赖.
胎儿对主要FA的有限内源生物合成强调了母亲营养和胎盘功能的关键作用.
这些发现强调了母亲摄入足够的必需的FA对于最佳胎儿发育的重要性.

关键词:

碳-13是一种碳-13的元素.脂肪酸是一种脂肪酸.胎儿生物合成的过程自然的丰富性自然的丰富性胎盘胎盘胎盘胎盘

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