晶状体衍生神经缩因子和精神分裂症谱系障碍:一个范围审查
Valerio Ricci1, Domenico De Berardis2, Giovanni Martinotti3
1Ospedale San Luigi Gonzaga, Università degli Studi di Torino, Italia; Regione Gonzole, 10, Orbassano 10043, Torino, Italia.
Current neuropharmacology
|December 16, 2024
概括
质衍生神经营养因子 (GDNF) 影响精神分裂症患者的认知功能和神经保护. 需要进一步的研究来澄清GDNF.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 精神疾病涉及改变大脑功能,影响现实感知.
- 神经发育假设将这些疾病与早期大脑发育中断联系起来.
- 质衍生神经营养因子 (GDNF) 对于神经元的生存和分化至关重要,特别是在多巴胺基神经元中.
研究的目的:
- 审查GDNF在精神分裂症谱系障碍和物质诱导精神病中的作用.
- 整合关于GDNF神经生物学机制的知识.
- 为了探索GDNF的治疗潜力.
主要方法:
- 从PubMed和Scopus (2001年起) 的文献范围审查.
- 数据提取的重点是GDNF水平,认知功能,抗精神病效应和遗传研究.
- 包括25项研究 (18项人类,7项动物).
主要成果:
- 在精神分裂症患者的GDNF血清水平上有不一致的发现.
- 大多数研究将GDNF水平与认知功能相关联.
- 动物研究强调了GDNF在应激反应,神经毒性和多巴胺信号传递中的作用.
- 遗传研究表明,GDNF多态度和精神分裂症易感性之间存在潜在的关联,尽管结果各不相同.
结论:
- 在精神分裂症中,GDNF显著影响认知功能和神经保护.
- 结果的变化表明了GDNF作用的复杂性.
- 在精神疾病中,GDNF的治疗潜力需要进一步研究其有效性和安全性.
- 强调需要综合生物标志物策略,基因疗法和精准医学.
更多相关视频
08:04Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
Published on: November 19, 2020
6.4K
10:47Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
Published on: March 2, 2018
10.0K
相关概念视频
01:29Biological Causes of Schizophrenia
51
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
51
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
529
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
529