急性胰腺炎后的症状负担及其与外分胰腺功能的相关性:一个多中心前性研究
Joseph Bejjani1, Stacey Culp2, Melica Nikahd2
1Division of Gastroenterology, Hepatology, and Nutrition, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.
Clinical and translational gastroenterology
|December 16, 2024
概括
胃肠道症状和体重减轻在急性胰腺炎 (AP) 后很常见. 下部外分胰腺功能与增加的症状负担和体重减轻相关,直到AP后12个月.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 胰腺学 胰腺学
- 临床研究 临床研究
背景情况:
- 胃肠道 (GI) 症状和体重减轻是急性胰腺炎 (AP) 的常见后果,但往往研究不足.
- 了解AP对肠道功能和患者福祉的长期影响,对于有效的管理至关重要.
研究的目的:
- 为了前性地评估患者在AP后的胃肠道症状和体重减轻的负担.
- 为了研究胃肠道症状,体重减轻和胰腺外分功能之间的相关性,直到AP后12个月.
主要方法:
- 一项前性多中心研究,涉及患有AP的成年人 (≥18岁).
- 系统测量GI症状负担 (使用15项跟踪器),人体测量和异位胰腺功能 (便弹性酶-1水平) 在入学时,3个月和AP后12个月.
- 多变量回归分析以确定与胃肠道症状负担相关的因素.
主要成果:
- 在97名参与者中,57%的人在AP后12个月经历了频繁的胃肠道症状.
- 在12个月内,更高的胃肠道症状负担与年轻的年龄,较低的并发症指数,吸烟,复发性AP以及酒精或异常病理病因有关.
- 在住院和12个月后的胃肠道症状和便弹性酶-1水平之间观察到显著的负相关性.
- 18.6%的参与者在12个月内体重减轻了10%以上,与表皮功能下降有关.
结论:
- 这项研究是第一个前性评估胃肠道症状负担和外分泌功能后AP的研究.
- 12个月内胰腺外分功能减少与增加的症状负担和体重减轻有关.
- 需要进一步的研究来定义和增强患者报告的AP后的结果.
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