在图雷特综合征和慢性症中全因和因特定死亡率
Lorena Fernández de la Cruz1, Kayoko Isomura1, Ralf Kuja-Halkola2
1Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Stockholm, Sweden.
Movement disorders : official journal of the Movement Disorder Society
|December 16, 2024
概括
图雷特综合征 (TS) 和慢性滴滴障碍 (CTD) 患者因所有原因死亡的风险增加了86%. 这种增加的死亡风险包括自然和非自然原因,强调需要更好地关注健康.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 图雷特综合征 (TS) 和慢性滴滴障碍 (CTD) 是神经系统疾病,可能与死亡率增加有关.
- 对于TS/CTD患者的具体死亡原因尚不清楚,需要进一步调查.
研究的目的:
- 估计TS/CTD患者全因和因特定死亡的风险.
- 为了比较TS/CTD个体与匹配的未受影响个体和兄弟姐妹之间的死亡风险.
主要方法:
- 使用瑞典国家患者登记册 (1973-2020) 进行的一项匹配队列研究.
- 包括10280名患有TS/CTD的个人和102,800名匹配的对照.
- 考克斯的比例危险回归模型被用来分析死亡原因登记册中的死亡数据,并对共变量进行调整.
主要成果:
- 患有TS/CTD的个体表现出86%的全因死亡风险增加 (HR:1.86,95% CI:1.65-2.11).
- 观察到自然原因 (神经,消化,呼吸系统疾病) 和非自然原因 (自杀,事故) 的死亡风险增加.
- 兄弟姐妹的比较证实了这些发现,表明这种关联不仅仅是由于家族因素.
结论:
- 患有TS/CTD的个体面临着明显更高的自然和非自然原因死亡风险.
- 这些发现强调了需要更多地关注TS/CTD患者的身体健康,因为某些死亡可能是可以预防的.
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