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相关概念视频

Overview of Exosomes01:36

Overview of Exosomes

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Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
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Updated: Jun 5, 2025

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
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细胞外囊泡在放射性核化疗法中的作用

J Constanzo1, J-P Pouget1

  • 1Nuclear Medicine Department, Institut Régional du Cancer de Montpellier (ICM), Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Équipe Labellisée Ligue Contre le Cancer, 208 rue des apothicaires, 34298 Montpellier, France.

Journal of radiation research
|December 16, 2024
PubMed
概括

向的放射性核酸治疗通过从被辐射的细胞中释放细胞外囊泡来刺激免疫系统. 这种方法有望克服对免疫检查点抑制剂的耐药性,并增强抗瘤免疫力.

科学领域:

  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学
  • 辐射疗法 辐射疗法

背景情况:

  • 传统的放射治疗可以诱导免疫细胞死亡.
  • 向放射性核素治疗 (TRT) 提供持续的低剂量辐射到瘤.
  • TRT显示出克服免疫检查点抑制剂耐药性的潜力.

研究的目的:

  • 检查TRT免疫调节效应的临床前和临床研究结果.
  • 研究细胞外囊泡在TRT诱导的抗瘤免疫中的作用.

主要方法:

  • 临床前研究的审查.
  • 临床发现的分析.
  • 从被辐射的细胞中释放细胞外囊泡的研究.

主要成果:

  • 被辐射的细胞释放出细胞外囊泡,激活免疫系统.
  • TRT可以刺激抗瘤免疫力.
  • 细胞外囊泡有助于TRT后的免疫激活.

结论:

  • 向的放射性核酸治疗激活了免疫系统.
  • 细胞外囊泡释放是TRT诱导的抗瘤免疫的一个关键机制.
关键词:
一个旁观者旁观者外基因组是外基因组的组成部分.微小的微小的微小的微小的微小放射性免疫疗法是一种放射性免疫疗法.放射性药物制品 放射性药物制品

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  • TRT是增强癌症免疫疗法的有希望的策略.